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SdrG C terminal protein domain
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SdrG C terminal protein domain : ウィキペディア英語版
SdrG C terminal protein domain

In molecular biology, the protein domain SdrG C terminal refers to the C terminus domain of an adhesin found only on the cell walls of bacteria. More specifically, SdrG is only found in gram-positive bacteria. This particular domain binds to a glycoprotein named fibrinogen. SdrG stands for serine-aspartate dipeptide repeats, which as its name suggests, contains repeats of two amino acids, serine and aspartate.
Gram-positive pathogens such as Staphylococci, Streptococci, and Enterococci, contain SdrG anchored to their cell walls; these proteins act as adhesins and help the bacteria adhere to the host tissues via a dock-lock-latch mechanism. This protein domain is of huge significance since it binds to fibrinogen, a glycoprotein involved in important processes such as haemostasis and coagulation. By understanding more about the way they attach to human cells, it is hope a therapeutic target can be developed to preven diseases such as nosocomial sepsis〔 which are caused by a bacterium which operates in this manner.
==Function==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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